Our guide to every Week 6 NFL game: Matchup previews, predictions, picks and nuggets

The Week 6 NFL schedule for the 2025 season brings immoderate intriguing matchups.

After a 206-yard rushing crippled past week, Panthers RB Rico Dowdle volition look to person a repetition show against the Cowboys, his erstwhile team. The Bucs volition big the 49ers for a showdown betwixt 4-1 teams. And the Lions sojourn the Chiefs' Arrowhead Stadium for the 2nd clip successful 3 seasons.

We person you covered with everything you request to know. Our NFL Nation reporters instrumentality you wrong the locker country with the champion happening they heard this week, and ESPN Research provides a cardinal stat to cognize and a betting nugget for each contest. Plus, analytics writer Seth Walder makes a bold prediction for each matchup, and phantasy expert Eric Moody shares fantasy football intel. We besides person Football Power Index (FPI) matchup prime ratings (out of 100) and crippled projections, and 3 analysts -- Pamela Maldonado, Moody and Walder -- springiness america last people picks for each game.

Let's get into the afloat Week 6 slate, which culminates with a "Monday Night Football" doubleheader betwixt the Bills and Falcons (on ESPN) and the Bears astatine Commanders (on ABC). (Game times are Sunday unless different noted.)

Jump to a matchup:
NYJ-DEN | LAR-BAL | SEA-JAX
ARI-IND | LAC-MIA | DAL-CAR
CLE-PIT | NE-NO | TEN-LV
SF-TB | CIN-GB | DET-KC
BUF-ATL | CHI-WSH

Thursday: PHI-NYG
Bye: MIN, HOU

Jets (0-5) astatine Broncos (3-2) successful London

9:30 a.m. ET | NFL Network | Matchup rating: 44.9/100
ESPN BET