Our guide to every Week 3 NFL game: Matchup previews, predictions, picks and nuggets

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  • Multiple Contributors

Sep 19, 2025, 06:35 AM ET

The Week 3 NFL schedule for the 2025 season brings immoderate intriguing matchups.

There are 2 battles betwixt undefeated teams, with the Rams visiting the Eagles and the Cardinals facing the 49ers. Injuries person affected a fewer apical QBs. The Bengals' Joe Burrow (toe), the Vikings' J.J. McCarthy (ankle) and the Jets' Justin Fields (concussion) are ruled out, and the 49ers' Brock Purdy (toe, shoulder) and the Commanders' Jayden Daniels (knee) are listed arsenic questionable. With that, their notable backups are looking to marque their mark. On Sunday night, the Chiefs look to excavation themselves retired of their archetypal 0-2 commencement with Patrick Mahomes against the Giants.

We person you covered with everything you request to know. Our NFL Nation reporters instrumentality you wrong the locker country with the champion happening they heard this week, and ESPN Research provides a cardinal stat to cognize and a betting nugget for each contest. Plus, analytics writer Seth Walder makes a bold prediction for each matchup, and phantasy expert Eric Moody shares fantasy football intel. We besides person Football Power Index (FPI) matchup prime ratings (out of 100) and crippled projections, and 3 analysts -- Pamela Maldonado, Moody and Walder -- springiness america last people picks for each game.

Let's get into the afloat Week 3 slate, which culminates with a "Monday Night Football" matchup betwixt the Lions and Ravens connected ESPN. (Game times are Sunday unless different noted.)

Jump to a matchup:
LAR-PHI | GB-CLE | LV-WSH
CIN-MIN | HOU-JAX | PIT-NE
NYJ-TB | IND-TEN | ATL-CAR
DEN-LAC

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