Sep 30, 2025, 11:40 AM ET
NFL's Week 5 slate gets underway with a matchup of NFC West rivals erstwhile the San Francisco 49ers sojourn the Los Angeles Rams connected "Thursday Night Football."
Sunday nighttime features different part rivalry erstwhile the Buffalo Bills big the New England Patriots.
The week wraps up with the Kansas City Chiefs hitting the roadworthy to instrumentality connected the Jacksonville Jaguars connected "Monday Night Football" (8:15 p.m. ET on ABC/ESPN).
Bye weeks besides begin, with the Atlanta Falcons, Chicago Bears, Green Bay Packers and Pittsburgh Steelers each disconnected this weekend.
Here's a look astatine the likelihood for each Week 5 game.
Odds arsenic of work time. For the astir existent odds, sojourn ESPN BET.
Jump to:
SF-LAR | MIN-CLE | LV-IND | DAL-NYJ
DEN-PHI | MIA-CAR | HOU-BAL | NYG-NO
TEN-ARI | TB-SEA | WSH-LAC | DET-CIN
NE-BUF | KC-JAX


San Francisco 49ers vs. Los Angeles Rams -5.5
Thursday, 8:15 p.m., Prime Video
Line movement: Opened Rams -3.5
Money Line: 49ers (+200); Rams (-240)
Total: 47.5; Opened: 46.5
FPI favorite: Rams by 2.4 with a 56.33% probability to triumph the crippled outright

Minnesota Vikings -3.5 vs. Cleveland Browns
Sunday, 9:30 a.m., NFL Net, NFL+
Money Line: Vikings (-200); Browns (+170)
Total: 36.5; Opened: 37.5
FPI favorite: Vikings by 5.6 with a 64.2% probability to triumph the crippled outright

Las Vegas Raiders vs. Indianapolis Colts -6.5
Sunday, 1 p.m., FOX
Money Line: Raide...

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