NFL Week 4 betting: Odds, lines and totals for every game

1 month ago 11

    Sep 22, 2025, 12:58 PM ET

    Week 4 gets underway with a matchup of NFC West rivals erstwhile the Arizona Cardinals big the Seattle Seahawks connected "Thursday Night Football."

    Sunday nighttime features Micah Parsons and the Green Bay Packers hitting the roadworthy to instrumentality connected the Dallas Cowboys.

    The week wraps up with a "Monday Night Football" doubleheader, arsenic the New York Jets sojourn the Miami Dolphins (7:15 p.m. ET connected ESPN) and the Denver Broncos big the Cincinnati Bengals (8:15 p.m. ET connected ABC).

    Here's a look astatine the likelihood for each Week 4 game.

    Odds arsenic of work time. For the astir existent odds, sojourn ESPN BET.

    Jump to:
    SEA-ARI | MIN-PIT | NO-BUF | LAC-NYG
    WSH-ATL | PHI-TB | CLE-DET | CAR-NE
    TEN-HOU | JAX-SF | IND-LAR | CHI-LV
    BAL-KC | GB-DAL | NYJ-MIA | CIN-DEN


    Seattle Seahawks vs. Arizona Cardinals -1.5
    Thursday, 8:15 p.m., Prime Video


    Money Line: Seahawks (-105); Cardinals (-115)
    Total: 43.5; Opened: 44.5
    FPI favorite: Cardinals by 0.8 with a 52.47% probability to triumph the crippled outright


    Minnesota Vikings -2.5 vs. Pittsburgh Steelers
    Sunday, 9:30 a.m., NFL Net, NFL+


    Money Line: Vikings (-150); Steelers (+130)
    Total: 40.5; Opened: 41.5
    FPI favorite: Vikings by 3.1 with a 57.18% probability to triumph the crippled outright


    New Orleans Saints vs. Buffalo Bills -15.5
    Sunday, 1 p.m., CBS


    Money Line: Saints (+900); Bills (-1800)
    Total: 47.5; Opened: 48.5
    FPI favorite: Bills by 13.3 with a 79.67% probability to triumph the crippled outright


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