NFL Week 2 betting: Odds, lines and totals for every game

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    Sep 11, 2025, 11:29 AM ET

    Week 2 gets started with a matchup betwixt the Washington Commanders and Green Bay Packers, 2 playoff teams from past season, astatine Lambeau Field connected Thursday night. Both teams won their Week 1 games.

    There are respective compelling matchups Sunday, including the Chicago Bears visiting the Detroit Lions (-4.5) successful aboriginal model and the Atlanta Falcons visiting the Minnesota Vikings (-4.5) connected "Sunday Night Football," but Week 2's biggest crippled is simply a Super Bowl rematch betwixt the Philadelphia Eagles (-1.5)and Kansas City Chiefs astatine Arrowhead Stadium.

    The week wraps up with a "Monday Night Football" doubleheader, with the Houston Texans (-2.5) histing the Tampa Bay Buccaneers (7 p.m. ET connected ABC/ESPN) followed by the Los Angeles Chargers (-3.5) visiting the Las Vegas Raiders (10 p.m. ET connected ESPN).

    Here's a look astatine the opening likelihood for each Week 2 game.

    For the astir existent odds, sojourn ESPN BET.

    Jump to:
    WSH-GB | SF-NO | JAX-CIN | BUF-NYJ
    NYG-DAL | NE-MIA | CHI-DET | LAR-TEN
    CLE-BAL | SEA-PIT | CAR-ARI | DEN-IND
    PHI-KC | ATL-MIN | TB-HOU | LAC-LV


    Washington Commanders vs. Green Bay Packers -3.5
    Thursday, 8:15 p.m., Prime Video


    Money Line: Commanders (+150); Packers (-175)
    Total: 48.5; Opened: 47.5
    FPI favorite: Packers by 3.6 with a 58.53% probability to triumph the crippled outright


    San Francisco 49ers -3.5 vs. New Orleans Saints
    Sunday, 1 p...

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