Betting Patriots-Bills: Game bets and four player props worth considering

1 month ago 10
  • ESPN

Oct 5, 2025, 11:59 AM ET

Sunday's slate of Week 5 games culminates with an AFC East matchup betwixt the New England Patriots and Buffalo Bills connected "Sunday Night Football."

New England (2-2) is coming disconnected a 42-13 shellacking of the Carolina Panthers, portion undefeated Buffalo disposed of the New Orleans Saints, 31-19.

The Bills and Patriots divided their bid past year, with some teams winning astatine home. They played doubly successful a three-week span past play but won't conscionable again this twelvemonth until Week 15.

Buffalo, the Super Bowl favourite astatine +425, has won its past 3 games by double-digits and is favored by 7.5 points for Sunday's tilt.

Here are the likelihood and trends, positive picks, props and investigation from our experts to assistance you stake Sunday night's game.

Note: Odds astatine clip of publication. For the latest updates, sojourn ESPN BET.


Jump to:
Game picks | Prop bets | Betting trends

Game bets

Bills -7.5 (-105)

Maldonado: This matchup is astir unit (or deficiency of). Josh Allen is elite successful some accumulation and efficiency. When teams get to him, he's human, but if they don't, he's unstoppable. That's a occupation for a New England squad ranked adjacent the bottommost of the league successful unit rate, completion complaint allowed, YPA allowed and touchdown rate. The Patriots person fixed up the second-most explosive plays successful the league, portion Buffalo leads the NFL successful some points per thrust (3.09) and explosive plays, truthful sustained scoring drives should travel easy. On the different side, Drake Maye's ratio collapses nether pressure, and Buffalo ranks 2nd successful creating it. Unless New England runs the shot efficiently, its discourtesy volition sputter. Over 4 quarters, Buffalo's endowment and unit triumph out.

Notable subordinate props, bets